Translational Physiology CALL FOR PAPERS Computational Modeling of Physiological Systems Discovery of the gene signature for acute lung injury in patients with sepsis
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چکیده
Judie A. Howrylak, Tamas Dolinay, Lorrie Lucht, Zhaoxi Wang, David C. Christiani, Jigme M. Sethi, Eric P. Xing, Michael P. Donahoe, and Augustine M. K. Choi Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital; Department of Environmental Health, Harvard School of Public Health; Pulmonary and Critical Care Unit, Massachusetts General Hospital, Boston, Massachusetts; and Department of Machine Learning, Carnegie Mellon University, Pittsburgh, Pennsylvania
منابع مشابه
Discovery of the gene signature for acute lung injury in patients with sepsis.
The acute respiratory distress syndrome (ARDS)/acute lung injury (ALI) was described 30 yr ago, yet making a definitive diagnosis remains difficult. The identification of biomarkers obtained from peripheral blood could provide additional noninvasive means for diagnosis. To identify gene expression profiles that may be used to classify patients with ALI, 13 patients with ALI + sepsis and 20 pati...
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Background and Objective: Due to the importance of acute kidney injury associated in patients with sepsis and the impact of various factors on mortality and hospital stay of these patients, this study was conducted to investigate the clinical features and risk factors for acute kidney injury in patients with sepsis. In addition, we examined whether the severity of acute kidney injury affected c...
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The effect of Positive End Expiratory Pressure (PEEP) on the hepatic elimination of low to moderate extraction ratio drugs has not been clearly defined. We prospectively investigated the effect of PEEP on the clearance of theophylline in 30 (20 males and 10 females) intubated critically ill adult patients with acute lung injury/acute respiratory distress syndrome (ALI/ARDS). The Mean (±SD) age ...
متن کاملp-Coumaric acid protects cardiac function against lipopolysaccharide-induced acute lung injury by attenuation of oxidative stress
Objective(s): Acute lung injury (ALI) has a high mortality rate and is characterized by damage to pulmonary system giving rise to symptoms such as histological alteration, lung tissue edema and production of proinflammatory cytokine. p-Coumaric acid (p-CA), as a phenolic compound, that is found in many types of fruits and vegetables has been reported to exhibit a thera...
متن کاملEffect of Lung Recruitment Maneuver in Children with Acute Lung Injury
Background Acute lung injury (ALI) is defined as PaO2/FiO2 less than 300 with bilateral pulmonary infiltrates, without pressure is the top of the left atrium. Early diagnosis and treatment of pediatric ALI and find new cases is very important. Accurate diagnosis and effective steps to treating these patients is essential in the outcome of ALI. This study was conducted to show the impact of recr...
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تاریخ انتشار 2009